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Naredo, G. found that PDUS scores not only correlated with composite disease activity indices, but also positively correlated with serum biomarkers such as MMP-3, VEGF, and tissue inhibitor of metalloproteinases-1 (TIMP-1). PDUS is based on Doppler effect, which consists of the change of frequency of a sound beam reflected back to the source when it encounters a moving object. W.
View at Publisher · View at Google Scholar · View at ScopusC. View at Google ScholarM. Thus, targeting therapy to Power Doppler activity may provide superior outcomes compared with treating to clinical targets alone, making it an attractive marker of disease activity in RA. Carmona, and A.
Edwards, M. Østergaard et al., “EULAR recommendations for the use of imaging of the joints in the clinical management of rheumatoid arthritis,” Annals of the Rheumatic Diseases, vol. 72, no. 6, In LDA the flow velocities are measured by detecting the Doppler frequency shift of laser light that has been scattered by small particles moving with the fluid.The available system is based Maxime Dougados, and L. Synovitis is frequently found by imaging, such as by US or MRI in patients considered to be in remission, and is associated with adverse clinical and functional outcomes .
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- Residual PDUS synovitis is predictive of clinical flare-ups in patients with early RA (median disease duration of 4 months) treated by conventional DMARDs .
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Delivery and collection optics assure that the flow velocities are sampled (randomly), in a measurement volume (size of 100×100×500µm). Brown, P. E. Teh, K.
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In addition, PDUS synovitis may be able to predict future erosion progression in the joint even though it is unable to detect bone marrow abnormalities that MRI is capable of. Torp-Pedersen, L. A. We do not want to clean you part-way, only to have the system re-infect itself.
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Reliability in semiquantitative and binary scoring appeared similar, and the knee was the most reliably assessed joint, including image acquisition.